MELANOMA. MODERN TREATMENT. VOLUME 5. PIOTR RUTKOWSKI

Discover the latest knowledge on melanoma treatment in the fifth part of the series edited by Prof. Dr. habil. med. Piotr Rutkowski. This is a compendium of knowledge for specialists and those interested in modern methods of fighting this cancer.

• Up-to-date information on the diagnosis and treatment of melanoma.
• Scientific editing by Prof. Dr. habil. med. Piotr Rutkowski.
• Detailed discussion of surgical and systemic treatment.
• Case descriptions with expert commentary.
• The topic of systemic therapy in patients with uveal melanoma.
• Possibilities of perioperative treatment in stage IIB and IIC.
• Analysis of the risk of disease recurrence and the benefits of systemic treatment.

Melanomas are malignant tumors derived from neuroectodermal melanocyte cells. In Poland, a steady increase in incidence is observed, with the number of newly registered cases reaching 4,500 per year. Advances in early diagnosis and the introduction of modern systemic treatment methods, based on immunotherapy and targeted therapy, have contributed to an increase in 5-year relative survival by approximately 20% by 2017.

The fifth part of the publication "Melanoma. Modern Treatment" focuses on the modern principles of surgical treatment, with particular emphasis on sentinel lymph node biopsy, perioperative and systemic treatment in the generalized stage. It is supplemented by case descriptions with expert commentary and the current topic of systemic therapy in patients with uveal melanoma, where tebentafusp is available.

The possibilities of perioperative treatment in stage IIB and IIC after a negative sentinel lymph node biopsy have been expanded by the introduction of reimbursed treatment with pembrolizumab or nivolumab. In adjuvant treatment, the risk of disease recurrence and the expected benefit of systemic treatment should be carefully assessed based on the results of NNT and NNH analysis, especially for patients with a lower risk of recurrence, i.e. in stage IIIA and IIB. It is also necessary to introduce preoperative treatment with combined immunotherapy in patients with clinical metastases in stage III, which is clinically and pharmacoeconomically justified.

PZWL Publishing House guarantees high quality and scientific reliability. The series "Melanoma. Modern Treatment" is an invaluable source of knowledge for oncologists, surgeons and all specialists involved in the treatment of skin cancer. This publication is a valuable support in daily clinical practice, enabling optimal therapeutic decisions to be made.

The book format is 236x155 mm, it has 102 pages and a paperback cover. The year of publication is 2025.