HEPATOCELLULAR CARCINOMA. A DIFFERENT CANCER THAN ALL OTHERS

Discover the publication from the "In the Specialist's Office" series, dedicated to hepatocellular carcinoma. This is an exceptional item, as this cancer, as the subtitle suggests, differs from others in many respects. It requires different approaches both in diagnostics and treatment. The authors, well-known and respected practitioners from various fields, describe in detail the etiopathogenesis, prophylaxis, and therapeutic methods used in patients with hepatocellular carcinoma.

• Comprehensive study of hepatocellular carcinoma.
• Detailed discussion of etiopathogenesis and prophylaxis.
• Description of local therapies (thermoablation, embolization).
• Discussion of surgical treatment.
• Systemic treatment, including adjuvant treatment.
• First and second line of treatment.
• Systemic HCC treatment in patients infected with HBV and/or HCV.

Hepatocellular carcinoma (HCC) is a serious health problem worldwide. Its incidence shows significant geographical variations, and risk factors include chronic infections with hepatitis B and C viruses, alcoholic liver disease, non-alcoholic fatty liver disease, and exposure to aflatoxins. Early detection of HCC is crucial for effective treatment, so regular screening is recommended for people at risk.

The diagnosis of HCC is based on imaging tests such as ultrasound, computed tomography, and magnetic resonance imaging, as well as on the determination of tumor markers, including alpha-fetoprotein (AFP). The treatment of HCC is complex and depends on the stage of the disease, liver function, and the patient's overall health. Treatment methods include surgical resection, liver transplantation, thermoablation, embolization, and systemic treatment.

Systemic treatment of HCC includes the use of molecularly targeted drugs such as sorafenib and lenvatinib, and immunotherapy, which stimulates the patient's immune system to fight the tumor. Immunotherapy, including checkpoint inhibitors, shows promising results in the treatment of advanced HCC. In addition, research is underway on new therapies such as kinase inhibitors, angiogenesis inhibitors, and gene therapies that may improve the prognosis of patients with HCC.

This publication is a valuable source of knowledge for specialists involved in the diagnosis and treatment of hepatocellular carcinoma. Thanks to the comprehensive discussion of various aspects of the disease, from etiopathogenesis to the latest therapeutic methods, this book will certainly contribute to improving the care of patients with HCC. It is a must-read for every doctor who wants to keep up with the latest achievements in the field of oncology.